Adiponectin appears to be intimately involved in several neurodegenerative disorders that are associated with CMV brain disease, such as epilepsy and ischaemic stroke [34] Therefore, adiponectin up-regulation in severe cases probably underlines the potential importance of inflammatory response on fetal brain lesions; this inflammatory response could be a target for future antenatal therapeutic intervention. The gene discussed is ADIPOQ; the disease is brain disorder.