HBD and nervous system disorder: Another major enrichment of the peptide biomarkers was found to be in “Neurological Disease” with 7 out of 13 peptides significantly enriched (Fig 5): beta-2-microglobulin (B2M), hemoglobin delta subunit (HBD), adiponectin (ADIPOQ), protein scribble homolog (SCRIB), T calcium channel alpha-1G (CACNA1G), DNA replication licensing factor (MCM6) and tuberin (TSC2).