CD274 and cancer: Monocyte-derived iregDC phenotype cells specifically expressing suppressive factors were observed in Mtb and HIV infection, and cancer, suggesting that suppressive DC arise from a monocyte origin in multiple situations of chronic disease characterized by continually high antigen loads, inflammation (i.e., IFNγ, IFN-I) and immunosuppression mediated by IL-10 and PDL1 [5, 39].