Using a mouse model of pulmonary tuberculosis, in which mice are aerosol infected with the highly virulent Erdman strain of Mtb, we observed that the PDL1 and IL-10 expressing DCs also exhibited heightened expression of the monocyte markers CCR2 and FcγRI in conjunction with increased levels of the iregDC markers CD39 and CD95 by 30 days after infection (Fig 7A), suggesting that similar to persistent LCMV, the DC that the produce suppressive factors IL-10 and PDL1 are of monocyte origin. Here, CD274 is linked to infection.