CD274 and viral infectious disease: MAVS-/- mice exhibited an increased number of stimDC, without a change in the number of iregDCs or IL-10 expression (although a small decrease in PDL1 expression on iregDC in MAVS-/- mice was observed; Fig 5B and S3D Fig), suggesting that MAVS signaling is important for the suppression of stimDC during persistent virus infection, but with minimal effect on iregDC differentiation.