PDGFRA and familial pancreatic carcinoma: MUC-1 is overexpressed in pancreatic cancers and has been shown to associate with HIF-1 alpha to drive the expression of hypoxia-induced oncogenes, including PDGF [19, 20], whose receptors, PDGFRalpha and PDGFRbeta regulate PDCA cell migration and metastasis [21, 22].