Reduction of adenosine uptake mediated by ENT1 was higher than 70% following one (0.230 ± 0.087 vs 0.060 ± 0.039 pmol • μmoles prot-1 • min-1, P value < 0.01) and four (0.200 ± 0.047 vs 0.053 ± 0.019 pmol • μmoles prot-1 • min-1, P value < 0.01) months from diabetes induction (Fig 1B). This evidence concerns the gene SLC29A1 and diabetes mellitus.