Viral outgrowth of both viruses in Raji DC-SIGN-CD4+-enriched T-cell blast co-cultures was significantly reduced (p = 0.033 and p = 0.012, respectively) when Raji DC-SIGN cells were pre-incubated with 5μg/ml BmA, indicating that BmA can block HIV-1 trans-infection (Fig 1E). This evidence concerns the gene CD4 and infection.