Especially, we discovered that the group with one of four haplotypes (T-T-T-T, C-T-T-T, C-C-T-T, and T-C-T-T) in CRHR2 showed a significantly lower score in perceived stress, anxiety, and depression in comparison with the group that did not have one of these haplotypes. The gene discussed is CRHR2; the disease is major depressive disorder.