CNOT7 and neoplasm: To test if reduction of Cnot7 expression in the stroma influenced metastasis, we then crossed C57BL/6J Cnot7+/- to FVB/NJ or Balb/cJ mice to generate Cnot7+/- and Cnot7+/+ mice that are immune-tolerant to the FVB- or BALB-derived tumor cells, respectively (Fig 3A).