Also, to the authors’ knowledge, the genes LGMN, SERPINH1, DPT, NREP, PLSCR4, FABP5, RPL22L1, TM4SF1, and MRCL3 have not been associated with either TSEs or protein misfolding disorders and their speculative role in resistance to prion infection is unclear at the moment. Here, TM4SF1 is linked to proteostasis deficiencies.