Treatment-mismatched comparisons (i.e., mock vs. scrapie and scrapie vs. mock) revealed similar results (S2 Fig and S1 File) as those mentioned above with the addition of genes ITM2B (up-regulated in highly permissive microglia), and CRLS1 and RPS20 (up-regulated in poorly permissive microglia). This evidence concerns the gene ITM2B and scrapie.