Macrophages and many inflammatory mediators including TNFα, MCP-1, ICAM-1, IL-1, IL-6, and IL-18 have been shown to be significantly increased in the diabetic kidney in patients with type 2 DN and correlated strongly with the progression of DN as indicated by proteinuria, interstitial fibrosis, and GFR decline [4, 5]. This evidence concerns the gene TNF and liver dysplastic nodule.