SLC5A2 and Glucose intolerance: Basic scientific research on SGLT2 deletion has also shown protective effects on pancreatic islets in animal models of T2DM [8]; in those study, the pancreatic β-cells of SGLT2 knockout mice fed with a high-fat diet were protected from hyperglycemia and glucose intolerance, which was explained by a 3-fold increase in urine output and a 500-fold increase in glucosuria due to SGLT2 deletion [8].