AKT1 and neoplasm: Anchored-lipid raft AKT protein has been extensively investigated in cancer cells (Figure 2a).62, 63 Its aberrant activation, contributing to tumor development and invasiveness,64, 65 correlates with increased lipid rafts in cancer cells.66, 67 Lipid raft disruption inhibits AKT activation63, 67, 68 and then reduces tumor cell proliferation (Figure 2a).66 Lipid rafts also exert crucial roles in cancer dissemination.