Oxidosqualene cyclase inhibitor (Ro 48-8071)117 or statins reduced tumor growth, angiogenesis and metastasis incidence in mouse carcinogenesis models (Table 1).118 However, despite promising preclinical results, the use of statins as monotherapy failed to improve patient outcome in many cancers119 because in addition to inhibiting cholesterol synthesis, statins increase circulating cholesterol supply through LDLR. The gene discussed is LDLR; the disease is neoplasm.