HLA-DRB1 and autoimmune hepatitis: We hypothesized that antibodies against gAChR exist in a subset of AIH patients with genetic susceptibility factors, including HLA. We genotyped the HLA-A, B, DRB1, and DQB1 genes in 260 AIH patients with or without anti-gAChR antibodies and evaluated the association between HLA genotype and the production of anti-gAChR antibodies.