The current study examined variation in nine key genes involved in circadian rhythm regulation or their transcription (BMAL1, CRY2, CSNK1E, KLF10, NPAS2, PER3, REV1, SENP3, TIMELESS) as predictors of epithelial ovarian cancer risk, histopathologic subtype, and invasiveness. Here, SENP3 is linked to ovarian carcinoma.