Although we are the first to describe increased expression of PEDF and PEDF-R in an induced model of ocular hypertension, our findings are consistent with previous studies that have established a role for PEDF signaling in RGC degeneration induced by ischemia [13], trophic factor withdrawal [5], and inherited ocular hypertension [11]. This evidence concerns the gene SERPINF1 and ocular hypertension.