Although we are the first to describe increased expression of PEDF and PEDF-R in an induced model of ocular hypertension, our findings are consistent with previous studies that have established a role for PEDF signaling in RGC degeneration induced by ischemia [13], trophic factor withdrawal [5], and inherited ocular hypertension [11]. The gene discussed is PNPLA2; the disease is ocular hypertension.