MMP3 and neoplasm: The subset of smokers shows a significant association of MMP3 tumor expression with OS (Figure 4D, N=820, HR=1.25 [95% CI 1.05-1.59], p=0.033), while an even stronger association of tumor MMP3 expression with poor OS is found in analysis of the patient subset of nonsmokers (Figure 4E, N=205, HR=2.58 [95% CI 1.32-4.05], p=0.0037).