SCD and cancer: Up-regulation of SREBF1c is in accordance with the up-regulation of its target SCD1. Indeed, hierarchical clustering indicated that SREBF2 and DHCR7 are clustered together in cancer cells as well as SREBF1 and SCD1. Interestingly, PDE8B clusters together with SREBF2 and DHCR7, although PDE8B has not been described to be associated with the MVA pathway or controlled by SREBFs.