However, among upregulated proteins in U266 cell line in comparison with RPMI-8226 cell line, the most enriched categories in KEGG-pathway were: cell adhesion molecules (CAMs) (ICAM1, ICAM3, PTPRC, PECAM1, HLA-A, ITGA4, ITGB1 and CD28) and viral myocarditis (also comprising ICAM1, HLA-A and CD28 plus DAG1, MYH9). The gene discussed is CD28; the disease is viral myocarditis.