In our study, despite upregulation of β2- microglubulin (light chain of MHC class I and a well- known poor prognosis biomarker in MM patients), HLA-A (heavy chain of MHC class I) was downregulated in MM-PC, suggesting a possible escape mechanism from cytotoxic T lymphocytes action by MM humans cells. The gene discussed is HLA-A; the disease is Miyoshi myopathy.