Indeed, our findings demonstrate that 2 weeks of mirtazapine treatment is sufficient to increase brain weight and re-establish somatosensory cortex architecture, normalize cardio-respiratory patterns and anxiety levels, abolish hopping behavior and restore the glutamatergic and GABAergic transmission in both cortex and brainstem in p42 MeCP2-null mice. The gene discussed is MECP2; the disease is Anxiety.