NADK and neoplasm: BC enrichment analysis of 40 multiplexed samples (four replicates for Input gDNA + three gDNA replicates from three individual cores for each four tumours) revealed a high-level enrichment for mutant NADK (NADKI90F; average 94% enrichment) in three out of four tumours (PT2–4) as well as a low-level enrichment (11%) for THAP Domain Containing 10, THAP10Y247F, in a single core of PT2 (Fig. 3d and Supplementary Fig. 3).