In terms of biological activity, 13S-HODE (74) has been shown to induce apoptosis in colorectal cancer cells by down-regulation of peroxisome proliferator-activated receptor (PPAR)-δ [107], also exhibiting remarkable tumor necrosis factor (TNF)-α inhibitory activity (52% and 98% inhibition at 50 μM and 100 μM, respectively) [60]. The gene discussed is TNF; the disease is colorectal cancer.