TEAD4 and colorectal carcinoma: Furthermore, with rescued expression of both wide type TEAD4 and a Y429H mutant (a mutation that impairs the interaction between TEAD4 and YAP/TAZ), they pointed out a YAP-independent manner of TEAD4 function in CRC, thus providing a novel mechanism of TEAD4 transcriptional regulation and its oncogenic role in CRC, independent of Hippo pathway [45].