Another regulatory mechanism of YAP2/TEAD4, which was involved in HCC tumorigenesis and drug resistance, was revealed by Mao et al. They found that SIRT1 deacetylated YAP2 protein in HCC cells, which strengthened the YAP2/TEAD4 association and enhanced YAP2/TEAD4 transcriptional activation, and thus finally promoted cell growth in HCC [44]. The gene discussed is TEAD4; the disease is hepatocellular carcinoma.