With regard to gemcitabine, human equilibrative nucleoside transporter 1 (hENT1) [7,8], ribonucleotide reductase M1 (RRM1) [9], B7H4 [10], DJ-1 [10], and heat shock protein 27 (HSP27; HSPB1) are considered to be prognostic markers of resistance to chemotherapy in pancreatic cancer. This evidence concerns the gene HSPB1 and familial pancreatic carcinoma.