HSPB1 and familial pancreatic carcinoma: On the contrary, Kang et al., reported that the ratio of phosphorylated HSP27 to non-phosphorylated HSP27 was significantly increased after gemcitabine treatment using pancreatic cancer cell lines MiaPaCa-2, HPAC, and BxPC3, and that an increase in the ratio of phosphorylated HSP27 to non-phosphorylated HSP27 was related to cell death [34].