Additionally, Guo et al., [33] reported that the overexpression of HSP27 increases the sensitivity to gemcitabine in the pancreatic cancer cell line, PL5, which is consistent with the in vivo results shown by Schafer et al. By contrast, Liu et al., [30] reported that the expression of HSP27 was decreased in a gemcitabine-resistant pancreatic cancer cell line, Capan-1. This evidence concerns the gene HSPB1 and pancreatic neoplasm.