FLNC and cancer: In 2015, by using SDS-PAGE and a coupled label-free MS approach, Qiao et al. identified 297, 419, and 265 dysregulated proteins with ≥2 folds in SGC-7901, MGC-803 and HGC-27 cells respectively when compared with GES-1 cells, and provided evidence showing that filamin C is a tumor suppressor, inhibiting cancer cells metastasis [30].