ACAN and disease of the tendon: Although expected, it is worthwhile noting that the semantic discovery strategy was able to identify as candidate genes several genes that have previously been associated with tendinopathy (ADAMTS14, COL5A1, COL11A1, FBN2, TIMP2, TNC)11, 13, 25, 26, 27, 28, 29  and anterior cruciate ligament ruptures (ACAN, BGN, DCN, KDR)22, 30.