In tumours, Collagen 1a1 (5.0 fold), Collagen 3a1 (5.0 fold), Collagen 4a1 (2.4 fold), Collagen 4a3 (2.1 fold), Collagen 5a1 (4.6 fold), Collagen 5a2 (11 fold), Collagen 18a1 (7 fold), Mmp3 (21 fold) Mmp14 (4.5 fold), Timp1 (2.5 fold), Cathepsin L (2.4 fold), Cathepsin S (2.3 fold), uPa (2-fold), Prolyl 4-hydroxylase alpha 1 (P4Ha1)(3.6 fold) and P4hb (−1.7 fold) were altered compared to controls35. The gene discussed is P4HA1; the disease is neoplasm.