In the tumour-adjacent non-malignant prostate tissue, Collagen 1a1 (4 fold), Collagen 1a2 (2.4 fold), Collagen 3a1 (5 fold), Collagen 4a1 (3.8 fold), Collagen 5a1 (3 fold), Collagen 5a2 (3.8 fold), Collagen 15a1 (2.5 fold), Collagen 28a1 (2.2 fold), Mmp3 (2.6 fold), Mmp14 (2.7 fold), Timp1 (3.3 fold), Elastin (3.4 fold), Cathepsin L (1.8 fold), Cathepsin S (2.4 fold), uPa (2 fold), P4ha1 (1.8 fold) showed changed expression compared to control prostate tissue35. The gene discussed is CTSS; the disease is neoplasm.