Whether tumour-suppressive vs. tumour-enhancing functions, are due to temporal changes in the relative importance of intracellular vs. extracellular LOX activity, different roles of LOX in the intra-tumoural vs. extra-tumoural environments, as well as temporal changes in available collagens and elastin to cross-link is unknown, and warrants further investigation. The gene discussed is ELN; the disease is neoplasm.