Previous studies have shown that AFAP1-AS1 is upregulated in esophageal adenocarcinoma, pancreatic ductal adenocarcinoma, lung cancer, and nasopharyngeal carcinoma, and high AFAP1-AS1 expression is associated with lymph node metastasis, perineural invasion, and poor survival [17–20]. The gene discussed is AFAP1; the disease is metastatic malignant neoplasm in the lymph nodes.