CNGA1 and retinitis pigmentosa 1: These observations strongly indicate that the c.1537G>A mutation leads to mistargeted protein products and suggest the pathogenesis of photoreceptor degeneration in the current pedigree might be the same as other known RP-causing CNGA1 mutations, which result from the paucity or lack of cGMP-gated channels in the plasma membrane of rod outer segments [4].