PIK3CA and cancer: Cell treatment with 1μM of the dual inhibitor PI3K/MTOR PI-103 for 24 h can trigger autophagic properties, as shown by the induced overexpression of LC3II protein levels, followed by a reduction in p62 protein levels in additional non BRAFV600E cancer cell lines Caco-2, DLD1 and HCT116 (Figure 3F).