In accordance to their effect on MEK pathway inhibition, presented in Figure 3A, PD0325901 was more efficient than PLX4720 in reducing cell viability in all three BRAFV600E colon cancer cell lines RKO, HT29 and Colo-205 after 24, 48 and 72 h treatments (Figure 3C). The gene discussed is MAP2K7; the disease is malignant colon neoplasm.