RNF2 and Ewing sarcoma: Among them are EZH2 and BMI-1 and, as Inmaculada Hernandez and Jaume Mora reported, RING1B (RNF2), which affects genes of heme biosynthesis, endothelial and neural development, and which they found to protect Ewing sarcoma cells from NFκB induced apoptosis through regulation of the sodium channel NaV1.6.