Kristiina Iljin reported on the results of a drugable siRNA cell viability screen in an inducible EWS-FLI1 shRNA Ewing sarcoma cell line interrogating nearly 7000 genes with 4 siRNAs per gene for EWS-FLI1 dependencies, which was performed as part of the “ASSET” project. The gene discussed is EWSR1; the disease is Ewing sarcoma.