Using the Infinium 450K methylation array to study promoter methylation, Oscar Tirado's group identified Ewing sarcoma specific inactivation of the PTRF/Cavin-1 gene, which, when co-expressed with the EWS-FLI1 activated target gene Caveolin-1 (CAV1), induced TP53 dependent cell death. This evidence concerns the gene EWSR1 and Ewing sarcoma.