DPYD and breast cancer: In addition to the above mentioned associations, we found 4 variants (rs2369049 close to TCL1A gene, rs2072671 within CDA gene; rs1801159 within DPYD gene, rs6214 within IGF1 gene) of genes listed as “related” to breast cancer medications by PharmGKB having a different distribution between the FGV and EUR/ExAC cohorts but for which the LOE of drug-variant association was not reported.