PTEN and esophageal squamous cell carcinoma: In esophageal squamous cell carcinoma (ESCC), the elevated miR-508-3p correlates with poor survival and activated PI3K/Akt signaling by targeting inositol polyphosphate-5-phosphatase J (INPP5J), phosphatase and tensin homologue (PTEN) and inositol polyphosphate 4-phosphatase type I (INPP4A) [39].