Breast cancer cells as exemplified by Hs578T, MDA-MB-231, BT-474 and T-47D have been reported to be inherently resistant to anoikis and it was concluded that this resistance does not involve the PI3-kinase/Akt or Grb2/Ras/MAP-kinase pathways [39]. This evidence concerns the gene GRB2 and breast carcinoma.