MAP2K5 and obesity due to melanocortin 4 receptor deficiency: We identified the nominally significant associations with obesity for effect alleles of 6 SNPs at FTO, SEC16B, TFAP2B, RBJ, MAP2K5 and CDKAL1 (ORs for the effect allele ranged between 1.19 and 1.41, nominal two-sided P < 0.05).