MAP2K5 and obesity due to melanocortin 4 receptor deficiency: The associations of obesity with SNP alleles at rs543874 of SEC16B (OR = 1.41, 95 % CI: 1.15-1.73) or at rs2241423 of MAP2K5 (OR = 1.34, 95 % CI: 1.12-1.59) seemed to be stronger in Chinese children than in Caucasians (OR = 1.10, 95 % CI: 1.06-1.14; OR = 1.07, 95 % CI: 1.04-1.10, respectively) [4], which was also indicated by non-overlapping 95 % confidence intervals in Fig. 1.