Critically we show HOTAIR and other lncRNA including tumor-associated lncRNAs HOXA cluster antisense RNA 2 (HOX-AS-2), Antisense non-coding RNA in the INK4 locus (ANRIL), long intergenic RNA Regulator of Reprogramming (linc-RoR), are overexpressed in UBC cell lines and are enriched in exosomes isolated from UBC cell lines. The gene discussed is HOTAIR; the disease is neoplasm.