NPC1L1 and coronary artery disorder: Polisecki et al. found that in Europeans, homozygous carriers of the minor alleles of four NPC1L1 sites (-18A>C, 1679C>G, V1296V, and U3_28650A>G) had 2–8% higher LDL-C levels and increased risk of coronary heart disease at baseline compared with homozygous carriers of the common alleles, owing to alterations in cholesterol absorption [8].