A typical example of this occurs at the angiopoietin-like 3 (ANGPTL-3) gene locus, associated with triglyceride (TG) levels, low-density lipoprotein cholesterol (LDL-C) levels, and CAD risk in several independent GWAS [1], [3], [4], where the functional variant(s) associated with these traits have not been identified. The gene discussed is ANGPTL3; the disease is coronary artery disorder.