SLC6A4 and Stroke: Given the distinct mechanisms thought to be involved in thrombo-inflammation and the described benefit of SSRI treatment of stroke patients, 5Htt-/- mice were subjected to the tMCAO model of ischemic stroke, where blood flow to the middle cerebral artery is blocked for 60 min before reperfusion, to further investigate the direct role of 5HTT and platelet stored 5-HT under ischemic conditions.