Briefly, the authors demonstrated that hepatocyte buds derived from progenitor cells (i.e., glutamine synthetase‐positive/EpCAM+ cells) and repopulate regions of extinct parenchyma in human cirrhosis by following a maturation process that involves dynamic expression of EpCAM and glutamine synthetase,49 allowing us to think that EpCAM might be required for stem cell maturation. The gene discussed is GLUL; the disease is Cirrhosis.