Treatment of CAC mice with embelin led to increased mRNA and protein expression of IFNγ and IL-12 (which are believed to be responsible for driving M1 polarization and anti-tumor activity) in the colonic mucosa, although statistic significance was only noted at days 19 and 45, but not at day 85 (Figure 3C and 3D). Here, IFNG is linked to neoplasm.