Interestingly, analyzing patients with defined TGF-β2 regulation in GSE1898/4024, we found a correlation between high TGF-β2 expression and a poorer survival rate (p < 0.01) (Supplementary Figure 4), but not with other clinicopathological parameters including AFP levels, tumor size, differentiation grade, cirrhosis, and hepatoblast vs. hepatocyte subtype (data not shown), further suggesting tumor-promoting effects of TGF-β2. Here, AFP is linked to Cirrhosis.