In a study including 87 ICC patients, TGF-β2 expression was linked to bad survival and its overexpression in the ICC stroma was significantly associated with ICC classification, microvascular invasion, and the presence of hilar lymph nodes [33], indicating TGF-β2 as a possible prognostic marker for the clinical outcome of ICC and HCC. The gene discussed is TGFB2; the disease is intrahepatic cholangiocarcinoma.