Although additional studies are needed, our findings (together with the previous works of Galic et al. and Weisberg et al.)raise a possibility that the beneficial effects of direct AMPK activators or salicylate-based drugs on inflammation and insulin resistance may be mediated, at least in part, by modulating macrophage CCR2 expression via NF-κB signaling. This evidence concerns the gene NFKB1 and Insulin resistance.