Compared with the controls, PCOS subjects had a significantly higher BMI, WC, fasting plasma glucose (FPG), FINS, HOMA-IR, TG, hs-CRP, and LBP(33.03±14.59 vs. 24.35±10.31 μg/ml, p<0.001, Fig 1).A decreased M value (8.21±3.06 vs. 12.31±1.72 mg/min/kg, p<0.001), SHBG (60.19±53.31 vs. 61.66±23.59 nmol/l, p<0.001), and HDL-c were also observed in PCOS. Here, SHBG is linked to polycystic ovary syndrome.