SOX2 and glioblastoma: Fig 5C shows the data for 135 cells having the SOX2+ HIF-1α+ RNApII-S2P-/low phenotype in glioblastomas, revealing that the localization of these cells tended to be determined by both of the parameters (y = 0.205x + 17.4; r = 0.34, n = 135, P < 0.01). The finding that most of the plots (80.7%) were distributed below the line y = x (gray region in Fig 5C) indicates that most SOX2+ HIF-1α+ RNApII-S2P-/low cells were localized in the zone between large ischemic necroses and the nearest blood vessels, and were closer to the necrotic side than to the blood vessels.