Fig 5C shows the data for 135 cells having the SOX2+ HIF-1α+ RNApII-S2P-/low phenotype in glioblastomas, revealing that the localization of these cells tended to be determined by both of the parameters (y = 0.205x + 17.4; r = 0.34, n = 135, P < 0.01). The finding that most of the plots (80.7%) were distributed below the line y = x (gray region in Fig 5C) indicates that most SOX2+ HIF-1α+ RNApII-S2P-/low cells were localized in the zone between large ischemic necroses and the nearest blood vessels, and were closer to the necrotic side than to the blood vessels. This evidence concerns the gene HIF1A and glioblastoma.