To discuss the roles of HIF-2α in the stemness and quiescence of glioblastoma cells within the peri-necrotic niche, which is the focus of our study, we compared the localization of HIF-2α+ cells with that of SOX2+ HIF-1α+ RNApII-S2P-/low cells. This evidence concerns the gene HIF1A and glioblastoma.