In this context, it is noteworthy that SOX2+ (or NANOG+) HIF-1α+ RNApII-S2P-/low cells were concentrated in the zones around necroses at a certain distance from the nearest blood vessels, where tumor cells are supposed to be exposed to moderate hypoxia and induced to express a moderate level of HIF-1α. The gene discussed is HIF1A; the disease is neoplasm.