For example, in animal model of hypoxia-induced pulmonary hypertension, expression of atrial natriuretic peptide (ANP)—a vasodilatory peptide secreted in pathologic conditions of increased myocardial load—was found earliest and most prominently in the RV insertion points and the interventricular septum (corresponding to NIF location on CMR)[23]. This evidence concerns the gene NPPA and pulmonary arterial hypertension.