Interestingly, upon viral infection, TRIM14 can link NEMO to the mitochondrial antiviral signalosome and further activate the NEMO–IKK α–IKK β complex, which phosphorylates IκBα, to drive its ubiquitination and proteasomal, allowing the subsequently activation of NF-κB signaling [16]. Here, TRIM14 is linked to viral infectious disease.