EHHADH and cancer: As shown in Figure 6C, proteomic analysis revealed that several key enzymes involved in fatty acid β-oxidation, including acyl-CoA dehydrogenase, enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase and beta-ketoacyl-CoA thiolase were all down-regulated in Rh2E2-treated LLC-1 cancer cells but not in normal lung fibroblasts (Supplementary Tables S3 & S4).