ESR1 and neoplasm: Similarly, the same was observed when varying degrees of family history were investigated individually (e.g., HR for women with first degree of family history: 0.99 (95% CI: 0.93–1.05) adjusted for age, ethnicity, SES, parity, menopausal status, invasive grade, positive nodes, tumor size, PR, ER, HER2 receptors, surgery type, and adjuvant treatments).