Induction of apoptosis after treatment with Sorafenib was shown for several types of cancer [17, 36, 37, 18, 38], but the mechanism behind the induction of apoptosis remain unclear, and has so far been attributed to its effects on ERK signalling, and not been linked to reduced AKT phosphorylation [39, 40, 20]. This evidence concerns the gene AKT1 and cancer.