Elevated fibrinogen plasma levels were associated with older age (p < 0.001,Fig 1A), menopause (p < 0.001,Fig 1B), advanced tumor stage (p = 0.034,Fig 1C), larger tumor size (p = 0.033,Fig 1D), lymphatic metastasis (p = 0.002,Fig 1E), and lymph node involvement (p < 0.001,Fig 1F), but not with histological grade (p = 0.543), ER (p = 0.966), PR (p = 0.422), HER2 (p = 0.466), Ki-67 (p = 0.720) or molecular type (p = 0.464). This evidence concerns the gene ERBB2 and neoplasm.