Finally, in multivariate analyses we adjusted for confounders, including lipid parameters (log PCSK9, total cholesterol, Apo A-I, Apo B), GFR, traditional CV risk factors (age, sex, prevalent CV disease) and statin intake; after full adjustment only GFR, age, prevalent CV disease and diabetes mellitus were independent predictors of CV outcome (Table 3). The gene discussed is PCSK9; the disease is diabetes mellitus.